Effects of indomethacin on systemic and renal haemodynamics during postnatal maturation in conscious lambs
Bibliographic record
Abstract
To investigate the role of endogenously produced prostaglandins in modulating systemic and renal haemodynamics during postnatal maturation, experiments were carried out in conscious, chronically instrumented lambs aged one to two weeks (group I, 10–14 days (n=6)) and six to eight weeks (group II, 40–58 days (n=13)). Mean arterial pressure (MAP), mean venous pressure (MVP) and renal blood flow (RBF) were measured for 5 min before (Control) and for 20 min after I.V. injection of vehicle (experiment one) and after 24–48 h, the non‐selective cyclooxygenase inhibitor, indomethacin (1 mg/kg, experiment two). Heart rate (HR) and renal vascular resistance (RVR) were calculated from the measured variables. MAP increased significantly in both groups by 2 mins after indomethacin, returning to control over the next 7 min. HR significantly decreased to reach a nadir at 3 mins in groups I and II, returning to Control by 7 min. A marked increase in RVR leading to a decrease in RBF also occurred within 2 min of administration of indomethacin in both groups; control levels were reached within 7 min. There were no effects of vehicle on any of the measured or calculated variables. These data provide new evidence to suggest that endogenously produced prostaglandins modulate systemic and renal haemodynamics during postnatal maturation in conscious lambs. These transient responses to indomethacin indicate a buffering effect of other vasoactive factors, such as nitric oxide, in the absence of endogenously produced prostaglandins.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".