Effects of indomethacin on systemic and renal haemodynamics during postnatal maturation in conscious lambs
Bibliographic record
Abstract
To investigate the role of endogenously produced prostaglandins in modulating systemic and renal haemodynamics during postnatal maturation, experiments were carried out in conscious, chronically instrumented lambs aged one to two weeks (group I, 10–14 days (n=6)) and six to eight weeks (group II, 40–58 days (n=13)). Mean arterial pressure (MAP), mean venous pressure (MVP) and renal blood flow (RBF) were measured for 5 min before (Control) and for 20 min after I.V. injection of vehicle (experiment one) and after 24–48 h, the non‐selective cyclooxygenase inhibitor, indomethacin (1 mg/kg, experiment two). Heart rate (HR) and renal vascular resistance (RVR) were calculated from the measured variables. MAP increased significantly in both groups by 2 mins after indomethacin, returning to control over the next 7 min. HR significantly decreased to reach a nadir at 3 mins in groups I and II, returning to Control by 7 min. A marked increase in RVR leading to a decrease in RBF also occurred within 2 min of administration of indomethacin in both groups; control levels were reached within 7 min. There were no effects of vehicle on any of the measured or calculated variables. These data provide new evidence to suggest that endogenously produced prostaglandins modulate systemic and renal haemodynamics during postnatal maturation in conscious lambs. These transient responses to indomethacin indicate a buffering effect of other vasoactive factors, such as nitric oxide, in the absence of endogenously produced prostaglandins.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".