Changes in the participation and expression of angiotensin II receptor At1 in heart and kidney of rats 6 weeks old with neonatal administration of de dexametasone and hyperbaric oxygen therapy
Bibliographic record
Abstract
One therapy that has demostrated that it normalize the cardiovascular responses of angiotensin receptor in one experimental model, is the hyperbaric oxygen therapy. It has been described the wide use of dexametasone during the neonatal period of time, having different and controversial responses. Dexametasone has been used commonly due to the improvement in the lung function into the respiratory difficulty syndrome. Some studies reports that the use of steroid during the neonatal period could have some beneficial effects but also it could induce cardiovascular and renal disorder during the development. As it has been described one of the main pathway involved is the renin‐aldosterone‐angiotensin system. Some researchers describe that steroids regulate the angiotensin II receptor and function. Objetive the main idea is to analize the modification of the expression of angiotensin II receptor in rat with administration neonatal of dexametasone with/without hyperbaric oxygen therapy. Methodology neonatal rat (2 days) were administrated with dexametasone and were divided in 2 groups one with hyperbaric oxygen therapy and the other without therapy. At the age of 6 weeks the animals were sacrificed, and the expression of the receptor At1 were measured in the heart and the kidney by PCR and inmunohistochemistry. Results The group only with dexametasone showed has major expression of At1 receptor, however the group with dexametasone and hyperbaric oxygen therapy has a reduction in the expression of this receptor. Conclusion This results could suggest that the hyperbaric oxygen therapy could normalize the expresion in this rats with dexametasone treatment, being beneficial because it could reduce the possibility of one cardiovascular pathology like and infarct. Support or Funding Information SIP, COFAA, IPN This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".