Effects of neonatal maternal separation on HVR are no longer present in middle‐aged female rats.
Bibliographic record
Abstract
Neonatal maternal separation (NMS) disrupts normal neurological development in mammals. The hypoxic ventilatory response (HVR) of adult male rats previously subjected to NMS is ∼25% greater than controls while the response of NMS females is reduced by ∼30% (Genest et al., 2004). To address the role of ovarian hormones on the respiratory phenotype observed in NMS females, we compared the HVR of adult (10–14 weeks old) with that of more mature females (53–60 weeks old) in which circulating estradiol and progesterone levels are significantly reduced. Pups subjected to NMS were placed in an incubator 3h/day for 10 consecutive days (P3 to P12). Controls were undisturbed. Rats were then reared normally until adulthood or middle age when HVR was measured with plethysmography (12% O 2 , 20 min). The HVR of middle‐aged females was greatly reduced compared to adults. The effects of NMS on HVR were attenuated in middle‐aged compared to younger adult females. Middle‐aged NMS females tended to have a higher HVR than controls, as observed in adult NMS males vs. controls. These results highlight the interaction between endogenous hormones and the respiratory phenotype observed in NMS animals. Supported by the CIHR.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".