The acute effects of Montbretin A (MbA), an á‐glucosidase inhibitor, on plasma glucose levels in the Zucker Diabetic Fatty rat
Bibliographic record
Abstract
Postprandial hyperglycemia is a risk factor for cardiovascular disease in diabetic patients. Acarbose and Miglitol, current therapeutic α‐glucosidase inhibitors, reduce postprandial hyperglycemia but, due to side effects, are not well tolerated. Research is ongoing to develop products that will minimize side effects and improve patient compliance. MbA, a purified glycosylated acyl flavonol, was isolated from extracts of the plant, Crocosmia crocomiflora. In vitro studies have shown MbA to be an inhibitor of both exquisite specificity and affinity for human pancreatic α‐amylase. The objective of this study was to determine if MbA was an orally effective glucose lowering agent in an animal model of type 2 diabetes. Animals were challenged with a starch load (2 g/kg) immediately followed by MbA (dose range: 0.5 to 10 mg/kg) administered by oral gavage. Plasma glucose levels were measured immediately prior to and at 30, 60, 90 and 120 minutes post‐administration. Acarbose 10 mg/kg was used as a control for glucose response. MbA prevented the starch‐induced increase in glucose levels at doses greater than 5 mg/kg. MbA (10 mg/kg) reduced plasma glucose levels by 38±3% as compared to 26±2% for acarbose in fatty treated animals. These data show that MbA was effective in lowering plasma glucose levels in vivo . Future studies will examine the chronic effects of oral MbA treatment on diabetes mellitus. Supported by CDRD and CIHR.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".