Activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the HI/HA syndrome
Bibliographic record
Abstract
Children with gain‐of‐function mutations in Glutamate Dehydrogenase (GDH) display hyperinsulinemia (HI) and hyperammonemia (HA). The HI has been clearly linked to an effect of increased GDH flux on insulin secretion. However, the origin of the HA is uncertain, particularly because hepatic GDH is considered to be close to thermodynamic equilibrium in vivo. We found increased ammonia release into the renal vein of rats infused with β‐2‐aminobicyclo[2.2.1]heptane‐2‐carboxylic acid (BCH), an activator of GDH. BCH infusion had no effect on the hepatic handling of ammonia as portal venous ammonia was effectively removed by the liver. BCH also caused increased ammonia production by isolated rat proximal tubules incubated with glutamine. BCH also increased ammonia production and flux through GDH in isolated rat kidney mitochondria incubated with glutamine. We conclude that activation of renal GDH may be responsible, at least in part, for the HA of the HI/HA Syndrome. (Supported by IGTC and CIHR).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".