The Effect of Exercise Training on Sympathetic Vasoconstrictor Responsiveness and Sympatholysis in Female Rats
Bibliographic record
Abstract
Our laboratory has previously reported that aerobic exercise training enhances contraction‐mediated inhibition of sympathetic vasoconstriction (sympatholysis) in male rats. Whether aerobic exercise training has a similar effect in female rats has not been established. Therefore, the purpose of the present study was to investigate the hypothesis that aerobic exercise training would blunt sympathetic vasoconstrictor responsiveness and enhance sympatholysis in female rats. Female Sprague‐Dawley rats were randomly assigned to sedentary (n=10) or treadmill exercise training (n=8) groups (15 min at 40 m/min, 5% gradient; 5 d/week) for 10 weeks. Following the completion of the sedentary behavior or exercise training intervention, rats were anaesthetized and instrumented for stimulation of the lumbar sympathetic chain and the measurement of arterial blood pressure and femoral vascular conductance (FVC). The triceps surae muscle group was stimulated to contract rhythmically at 60% of maximal contractile force. The percentage change of FVC (Δ%FVC) in response to sympathetic stimulation delivered at 2 and 5 Hz was determined at rest and during contraction. At rest, sympathetic vasoconstrictor responsiveness (Δ%FVC) was not different (p>0.05) between sedentary and exercise trained rats in response to sympathetic stimulation delivered at 2Hz (Sedentary: −39 ± 12 %; Exercise Trained: −45 ± 9 %) and 5Hz (Sedentary: −57 ± 8 %; Exercise Trained: −61 ± 9 %). Muscle contraction blunted (p<0.05) sympathetic vasoconstrictor responsiveness in both sedentary and exercise trained rats and the magnitude of sympatholysis was not different (p>0.05) between sedentary (2Hz: 24 ± 8 %; 5Hz: 29 ± 10 %) and exercise‐trained (2Hz: 30 ± 10 %; 5Hz: 29 ± 13 %) rats. These data demonstrate that aerobic exercise training does not alter sympathetic vasoconstrictor responsiveness or contraction mediated inhibition of sympathetic vasoconstriction (sympatholysis) in female rats. Further investigation is required to determine why female rats respond differently to exercise training than male rats. Support or Funding Information Natural Sciences and Engineering Research Council of Canada, Canadian Foundation for Innovation, and Alberta Advanced Education and Technology. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".