Bibliographic record
Abstract
Autoimmune hepatitis (AIH) is a disease of unknown aetiology, in which a progressive destruction of the hepatic parenchyma occurs. This disease follows a chronic, but fluctuating course. AIH spontaneously progresses towards cirrhosis and liver failure, but often shows a relatively good response to immunosuppressive treatment1. It is characterized by a female preponderance, marked hyper-gammaglobulinaemia, circulating autoantibodies, low levels of complement factor 4 and a high prevalence of HLA B8 and DR3 and DR4 haplotypes1. Other autoimmune disorders are frequently found in patients with AIH as well as in first-degree relatives1-3. These clinical and laboratory observations led to the hypothesis that AIH is a multifactorial disease. Autoimmune associated disorders are of B and T lymphocyte origin, and other anomalies of the immune system, such as low levels of circulating IgA, are not uncommon. Two types of AIH are currently recognized according to the nature of the autoantibody detected in children at the time of diagnosis. Patients with AIH type 1 display anti-smooth muscle antibodies (SMA) and/or anti-nuclear antibodies (ANA) in their sera. AIH type 2 is characterized by anti-liver kidney microsome (LKM1) and/or anti-liver cytosol type 1 antibodies (LCl)2,3.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".