Age dependent cardiovascular responses to angiotensin II (ANG II) in conscious mice
Bibliographic record
Abstract
ANG II plays a critical role in regulating cardiovascular homeostasis. By binding to type 1 receptors, ANG II increases vascular resistance and thereby arterial pressure. The expression of type II receptors, which promote vasodilatation, is upregulated in the post natal period and may result in different cardiovascular responses to ANG II early in life. This study was designed to evaluate cardiovascular responses to ANG II in two groups of conscious mice (Group I: 4 weeks, n=5; Group II: 10–14 weeks, n=8). Experiments consisted of measurements of mean arterial pressure (MAP) and heart rate (HR) for 20 min before (Control, C) and 30 min after I.V. infusion of one of seven doses of ANG II (0–10 ng/g/min). ANG II was associated with a dose‐dependent increase in MAP in both groups reaching a maximum at 5.0 ng/g/min (EC 100 ) in group I (C 99±11; Max 126±16 mmHg) and 0.5 ng/g/min (EC 100 ) in group II (C 113±9, Max 139±22 mmHg). The time to peak was longer and the duration of the MAP response was less in group I as compared to group II. In group I, in response to EC 100 , HR was decreased from 563±103 (C) to 467±62 bpm, yet remained unchanged in group II from 503±87 bpm (C). These results provide evidence that the cardiovascular responses to acute ANG II infusion in young mice are developmentally regulated. Mechanisms underlying these age‐dependent differences are not yet clear but could reflect developmental regulation of ANG II receptors.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".