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Record W3177542085 · doi:10.1007/s12028-021-01260-x

Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

2021· article· en· W3177542085 on OpenAlex
Jan Claassen, Yama Akbari, Sheila Alexander, Mary Kay Bader, Kathleen Bell, Thomas P. Bleck, Mélanie Boly, Jeremy Brown, Sherry Chou, Michael N. Diringer, Brian L. Edlow, Brandon Foreman, Joseph T. Giacino, Olivia Gosseries, Theresa Green, David M. Greer, Daniel F. Hanley, Jed A. Hartings, Raimund Helbok, J. Claude Hemphill, Holly E. Hinson, Karen G. Hirsch, Theresa Human, Michael L. James, Nerissa Ko, Daniel Kondziella, Sarah Livesay, Lori Madden, Shraddha Mainali, Stephan A. Mayer, Victoria McCredie, Molly McNett, Geert Meyfroidt, Martin M. Monti, Susanne Muehlschlegel, Santosh B. Murthy, Paul Nyquist, DaiWai M. Olson, J. Javier Provencio, Eric S. Rosenthal, Gisele Sampaio Silva, Simone Sarasso, Nicholas D. Schiff, Tarek Sharshar, Lori Shutter, Robert D. Stevens, Paul Vespa, Walter Videtta, Amy K. Wagner, Wendy Ziai, John Whyte, Elizabeth Zink, José I. Suárez

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueNeurocritical Care · 2021
Typearticle
Languageen
FieldMedicine
TopicTraumatic Brain Injury Research
Canadian institutionsUniversity of Toronto
FundersNational Center for Advancing Translational SciencesNational Institute of Neurological Disorders and StrokeNational Institutes of Health
KeywordsNeurointensive carePersistent vegetative stateMedicineComa (optics)ConsciousnessDeliverableEngineering ethicsPsychiatryIntensive care medicineMinimally conscious statePsychologyNeuroscienceEngineering

Abstract

fetched live from OpenAlex

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.371
Threshold uncertainty score0.360

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.356
Teacher spread0.311 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it