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Record W3184459037 · doi:10.82308/35420

Developmental risks of paternal age during adrenarche

2021· article· en· W3184459037 on OpenAlexfundno aff
Ji Min Lew

Bibliographic record

VenueeScholarship@McGill (McGill) · 2021
Typearticle
Languageen
FieldMedicine
TopicBirth, Development, and Health
Canadian institutionsnot available
FundersMcGill University Health CentreMcGill University
KeywordsAdrenarchePsychologyDevelopmental psychologyMedicine

Abstract

fetched live from OpenAlex

There is a large body of evidence supporting the notion that maternal factors, such as age and mental health, affect her child’s development. In contrast, much less is known about the paternal contribution to child outcomes, though preliminary investigations have identified specific developmental risks linked to extremes of paternal age, such as lower IQ and/or behavioral problems. Hence, fathers, like mothers, influence their child’s development, whether through prenatal biological alterations in the father’s sperm cells, postnatal variations in the household and learning environment, and/or quality of the father-child or couple relationships. Any developmental risks linked to paternal age may be amplified during middle childhood (6-8 years old) as children graduate from kindergarten and adjust to the more demanding environment of elementary school. This developmental stage also coincides with a unique endocrine event shown to influence brain development, adrenarche. As such, this project aims to investigate whether the child’s androgen and cortisol production during adrenarche moderates the relationships between father’s age (alone or in relation to mother’s age) and the child’s cognition and behavior during the school transition. Data from a sub-cohort of the 3D study (n=61) was collected on parents and children from the 1st trimester of pregnancy to 6-8 years postpartum. We found extremes of paternal age and parental age gaps to interact with the child’s androgen to cortisol ratio in moderating behavioral risk, especially measurable differences in externalizing symptoms such as conduct or inattention/hyperactivity symptoms. Based on these findings, we propose a new conceptual model for father-child risk transmission based on the level of “fitness” between a father’s age and his child’s hormonal profile and discuss future implications of this model in research and clinical practice

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.016

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.073
GPT teacher head0.306
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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