Investigating the Effects of Oxidative Stress Prevention Using DNA Aptamer (Aptamin C®) in Keratinocyte
Bibliographic record
Abstract
Oxidative stress is one of the leading causes of various diseases. Oxidative stress conditions occur when reactive oxygen species (ROS) levels exceed cell defense mechanisms. Antioxidants are effective against ROS, a major factor in oxidative stress. Antioxidants play important roles in our body by scavenging free radicals, thereby preventing them from damaging biological molecules. Vitamin C is essential for various physiological functions such as the synthesis of collagen and neurotransmitters, and it is a major antioxidant. Although vitamin C is widely used in cosmetic and therapeutic products, it easily undergoes oxidation by air, pH, temperature, and UV light, thereby decreasing its potency as an antioxidant and reducing the shelf-life of products containing vitamin C. To overcome this drawback, we developed Aptamin C®, an innovative single-strand DNA aptamer that maximizes the antioxidant efficacy of vitamin C by binding to its reduced form and delaying its oxidation. To investigate the effect of Aptamin C® and vitamin C complex on human skin, we performed both in vitro and clinical tests. We observed that the Aptamin C® and vitamin C complex had effective ROS-scavenging and anti-inflammatory effects.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".