Estudio experimental piloto tras cirugía del uso de un complejo alimenticio en deportistas para la protección del cartílago articular de rodilla: Un estudio funcional y bioquímico
Bibliographic record
Abstract
espanolEn este estudio experimental doble ciego se evalua la eficacia de la suplementacion condroprotectora (Carticure Plus®, 5000 mg Colageno (Peptidos Bioactivos) altamente asimilable, 1500 mg Glucosamina clorhidrato, 1200 mg Condroitin sulfato, 1,1 mg Cobre, 80 mg Vitamina C, 2 mg Manganeso) en pacientes con patologia ligamentosa y meniscal que han requerido cirugia artroscopica. Se seleccionaron 12 pacientes con lesion ligamentosa y 12 pacientes con meniscopatia a los que se les procedio a la medicion de distintos marcadores inflamatorios mediante ELISA, colageno 2A y acido hialuronico, ademas de a la evaluacion del dolor asi como la funcionalidad y calidad de vida a traves de EVA (Escala Visual Analogica), WOMAC (Western Ontario McMaster Universities Osteoarthritis Index) y KOOS (Knee Injury and Osteoarthritis Outcome Score). Se observaron diferencias estadisticamente significativas de mejoria clinica a favor de Carticure Plus®, con una mejora de la capacidad funcional de la escala WOMAC del 76 % frente a un 53% del placebo para el conjunto de pacientes y con una clara mejoria en el primer mes en lesion meniscal, en mejora de las actividades de la vida diaria (KOOS), Carticure Plus® 31% frente a placebo -1%, actividad deportiva (Carticure Plus® 41% vs Placebo 13,2%), actividades deportivas y recreativas (Carticure Plus® 128% vs Placebo 10,4%). Por otro lado, en lesion ligamentosa se observa una mejoria en calidad de vida (KOOS) Carticure Plus® 75% vs Placebo -8,8% y dolor (KOOS) Carticure Plus® 49,6% vs Placebo 0,3% en el primer mes respecto al basal. En el conjunto de pacientes, el dolor (KOOS) Carticure Plus® 31,4% vs Placebo 1,3% y actividades de la vida diaria (KOOS) Carticure Plus® 43,9% vs Placebo 27,1% en el tercer mes respecto al basal se asocian a una mejora a Carticure Plus® en comparacion al placebo. A pesar del pequeno tamano muestral, es destacable el hecho de haber encontrado diferencias estadisticamente significativas que podria presuponer la eficacia de Carticure Plus®. EnglishThis double-blind experimental study evaluates the efficacy of chondroprotective supplementation (Carticure Plus®, 5000 mg Collagen – Bioactive Peptides, 1500 mg Glucosamine Hydrochloride, 1200 mg Chondroitin Sulfate, 1.1 mg Copper, 80 mg Vitamin C, 2 mg Manganese) in patients with meniscal and ligament pathology who have required arthroscopic surgery. 12 patients with ligamentous injury and 12 patients with meniscopathy were selected, who underwent the measurement of different inflammatory markers using ELISA, collagen 2A and hyaluronic acid, in addition to evaluating pain as well as functionality and quality of life through VAS (Visual Analogue Scale), WOMAC (Western Ontario McMaster Universities Osteoarthritis Index) and KOOS (Knee Injury and Osteoarthritis Outcome Score). Statistically significant differences of clinical improvement were observed in favor of Carticure Plus®, with an improvement in the functional capacity of the WOMAC scale, 76% Carticure Plus® vs 53% placebo, for all patients and with a clear improvement in the first month in meniscal injury, in improvement of the activities of daily life (KOOS), Carticure Plus® 31% vs placebo -1%, sports activity, (Carticure Plus® 41% vs placebo 13,2%) and sports and recreational activities (KOOS) (Carticure Plus® 128% vs Placebo 10,4%). On the other hand, in ligamentous injury an improvement in quality of life (KOOS) Carticure Plus® 75% vs Placebo -8,8% and pain (KOOS) Carticure Plus® 49,6% vs Placebo 0,3% was observed in the first month compared to the baseline. In the patient group, pain (KOOS) Carticure Plus® 31,4% vs Placebo 1,3% and activities of daily living (KOOS) Carticure Plus® 43,9% vs Placebo 27,1% in the third month from baseline, are associated with an improvement due to Carticure Plus® when compared to the placebo group. Despite the small sample size, it is remarkable the fact that statistically significant differences have been found, the efficacy of Carticure Plus® could be assumed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".