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Record W3188941082 · doi:10.1002/mp.15167

Dosimetry of a novel converging X‐ray source for kilovoltage radiotherapy

2021· article· en· W3188941082 on OpenAlexaff
Tyler Stalbaum, L. D. Partain, M Weil, Joon Kim, Jae Yong Han, Michael J. Plies, Hong Chen, V. Ziskin, Magdalena Bazalova‐Carter, Samuel M. Song, R. E. Rand, Douglas P. Boyd

Bibliographic record

VenueMedical Physics · 2021
Typearticle
Languageen
FieldPhysics and Astronomy
TopicAdvanced Radiotherapy Techniques
Canadian institutionsUniversity of Victoria
FundersNational Cancer InstituteNational Institutes of Health
KeywordsDosimetryCollimated lightIsocenterImaging phantomOpticsLinear particle acceleratorMaterials scienceDose profileX-ray opticsCollimatorBeam (structure)PhysicsX-rayNuclear medicineLaser

Abstract

fetched live from OpenAlex

Abstract Purpose The objective of this work was to evaluate phantom dosimetry of a novel kilovoltage (kV) X‐ray source, which employs a stationary tungsten anode and a linearly swept scanning electron beam. The source utilizes converging X‐ray collimation along with orthogonal mechanical rotation to distribute surface flux over large area. In this study, this was investigated as a potential solution to fast‐falloff limitations expected with kV radiotherapy. This was done with the aim of future clinical development of a lower cost radiotherapy alternative to megavoltage (MV) linac systems. Methods Radiochromic film was employed for dosimetry on the kV X‐ray source of the linear‐converging radiotherapy system (LCRS). The source utilizes charge particle optics to magnetically deflect and focus an electron beam along a stationary, reflection tungsten target in an ultra‐high‐vacuum stainless‐steel chamber. Resulting X‐rays were collimated into converging beamlets that span a large planar angle and converge at the system isocenter. In this study, radiochromic film dosimetry was done at 140 and 145 kVp for a designated planning treatment volume (PTV) of 4 cm diameter. An acrylic phantom was employed for dose distribution measurements of stationary and rotational delivery. Film dosimetry was evaluated in planes parallel to the source X‐ray window at various depths, as well as in the plane of gantry rotation. Results At 140 and 145 kVp and using a collimated 4 cm square field at depth, lesion‐to‐skin dose ratio was shown to improve with additional beams from different relative source positions, where the different beams are focused at the same isocenter and do not overlap at the phantom surface. It was only possible to achieve a 1:1 Dmax‐to‐surface ratio with four delivery beams, but the ratio improved to 4:1 with 12 beams, focused at the same isocenter depth of 7.8 cm in an acrylic phantom. For the tests conducted, the following Dmax‐to‐surface ratios were obtained: 0.4:1 lesion‐to‐skin ratio for stationary delivery from one entry beam, 0.71:1 lesion‐to‐skin ratio was obtained for two beams, 1.07:1 ratio for four beams, and 4:1 for 12 beams. Dose‐depth profiles were evaluated for stationary and rotational dosimetry. Additionally, rotational dosimetry was measured for a case more analogous to a clinical scenario, where the isocenter was located at an off‐center simulated lesion. Conclusions The results demonstrate potential dose‐depth improvements with kV arc therapy by distributing the surface flux with a wide converging beam along with perpendicular mechanical source rotation of the LCRS. The system delivered tolerable dose to a large surface area when a threshold of multiple, separated beams was reached. The radiochromic film data support the feasibility of the construct of the LCRS kV radiotherapy system design.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.294
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2021
Admission routes1
Has abstractyes

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