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Cancer mortality in relatives of desmoid sarcoma patients

2023· article· en· W3190075046 on OpenAlexaboutno aff
Louise C. Strong, Anita Schnitman

Bibliographic record

VenueRevista Brasileira de Cancerologia · 2023
Typearticle
Languageen
FieldMedicine
TopicSoft tissue tumor case studies
Canadian institutionsnot available
Fundersnot available
KeywordsGrandparentProbandMedicineDemographyFamily historySarcomaCancerStandardized mortality ratioIncidence (geometry)PopulationOffspringPediatricsInternal medicinePsychologyGeneticsPathologyEnvironmental healthBiology

Abstract

fetched live from OpenAlex

Desmoid sarcoma patients from the U.S. and Canada, diagnosed under the age of 16 years and referred to the University of Texas, M.D. Anderson Hospital - MDAH - between 1944 and 1975 were surveyed. Family information was collected for grandparents, parents, parental siblings, proband offspring and siblirtgs. Expected mortality was calculated by applying age-race-sex specific U.S. mortality rates to the person-years at risk. Standardized mortality ratio's - SMR- were calculated. Among 429 relatives of 26 desmoid sarcoma probands no overali cancer excess was found, observed/expected = 13/24.7. The risk among parents, the ones more informative for genetic analysis were also not significant, observed/expected = 2/1.83. An updated follow-up of incidence data of the study population and of the general population is suggested in the years to come, and in doing so, the inclusion of all familly members history should pull the results to a number closer to reality.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.702

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.051
GPT teacher head0.356
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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