Front Cover: Early‐Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2‐Cyanobenzothiazole/1,2‐Aminothiol Bioorthogonal Click Reaction (ChemistryOpen 3/2018)
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The Front Cover shows an innovative methodology for the regioselective labeling of peptides. Early-stage incorporation of a clickable handle during SPPS provides flexibility for the functionalization of peptide-based targeting vectors. Once the click handle has been ideally positioned, an imaging probe is conjugated to the targeting vector by 2-cyanobenzothiazole (CBT)/1,2-aminothiol cycloaddition. This key reaction is as easy as just “one click”. The labeling reaction is rapid, biocompatible, orthogonal, and highly efficient. It offers a nearly ideal labeling strategy for peptides and a powerful tool for the development of novel imaging agents for biomedical applications. More information can be found in the Communication by K.-T. Chen et al. on page 256 in Issue 3, 2018 (DOI: 10.1002/open.201700191).
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it