X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.330 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
The patients' blood plasmacytoid dendritic cells (pDCs) produce low levels of type I IFNs in response to SARS-CoV-2. Overall, X-linked recessive TLR7 deficiency is a highly penetrant genetic etiology of critical COVID-19 pneumonia, in about 1.8% of male patients below the age of 60 years. Human TLR7 and pDCs are essential for protective type I IFN immunity against SARS-CoV-2 in the respiratory tract.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Science Immunology
- Topic
- Respiratory viral infections research
- Field
- Medicine
- Canadian institutions
- —
- Funders
- NHLBI Division of Intramural ResearchNational Institute of Allergy and Infectious DiseasesUniversité Claude Bernard Lyon 1Agencia Estatal de InvestigaciónInstituto de Salud Carlos IIIQatar National Research FundUniformed Services University of the Health SciencesUniversity of California, Los AngelesNational Institutes of HealthUniversité de ParisCenter for Innovative MedicineSorbonne UniversitéInstituto Colombiano de Crédito Educativo y Estudios Técnicos en el ExteriorAgence Nationale de la RechercheUniversität InnsbruckLékařská fakulta, Masarykova univerzitaUniverzita Karlova v PrazeMinisterio de Ciencia e InnovaciónUniversitat Autònoma de BarcelonaUniversité de LyonRegione LazioMansoura UniversityMedical Research CouncilTartu ÜlikoolUniversità degli Studi di BresciaCentral European Institute of TechnologyFondation du SouffleCentre Hospitalier Universitaire VaudoisUniversité de LausanneInstituto Tecnológico y de Energías RenovablesGöteborgs UniversitetUniversidade de São PauloScience for Life LaboratoryUniversidad de AntioquiaHospices Civils de LyonMedizinische Universität InnsbruckCentre National de la Recherche ScientifiqueFonds National de la Recherche LuxembourgMinistero della SaluteSidra MedicineInstitut National de la Santé et de la Recherche MédicaleUniversiteit GentFederal Aviation AdministrationInvitaeImperial College LondonNorthwell HealthInstitut des maladies génétiques ImagineUniversitair Ziekenhuis GentInstituto Nacional de PediatriaBC Children's HospitalLeidosTel Aviv UniversityUniversidad de La LagunaMasarykova UniverzitaDepartamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)Frederick National Laboratory for Cancer ResearchGenentechMurdoch Children's Research InstituteEuropean CommissionHelsingin YliopistoChildren's Healthcare of AtlantaNational Human Genome Research InstituteAarhus UniversitetshospitalAarhus UniversitetHarvard UniversityDivision of Intramural Research, National Institute of Allergy and Infectious DiseasesStockholms Läns LandstingUniversity of New South WalesKU LeuvenFondation pour la Recherche MédicaleInstitució Catalana de Recerca i Estudis AvançatsCliniques Universitaires Saint-LucEmory UniversityChildren’s Hospital of Wisconsin Research InstituteNational Center for Advancing Translational SciencesMercatus Center, George Mason UniversityJPB FoundationAssistance publique-Hôpitaux de ParisUniversità degli Studi di Milano-BicoccaInstitut Gustave-RoussyUniversité de BourgogneUniversity of PennsylvaniaFisher Center for Alzheimer's Research FoundationLudwig Institute for Cancer ResearchSahlgrenska AkademinHenry M. Jackson FoundationFondation Bettencourt SchuellerSt. Giles FoundationUniversidad de NavarraGeorge Mason UniversityKaradeniz Teknik ÜniversitesiKarolinska InstitutetYale UniversityUniversité Hassan II de CasablancaGilead SciencesBrigham and Women's HospitalGeorgia Clinical and Translational Science AllianceHoward Hughes Medical Institute
- Keywords
- TLR7PneumoniaImmunologyAsymptomaticCohortBiologyPopulationMedicineInternal medicineGastroenterologyImmune systemInnate immune systemToll-like receptor
- Has abstract in OpenAlex
- yes