Multiple lung nodules, eosinophilia and severe asthma
Bibliographic record
Abstract
We present an unusual clinical scenario of a severe asthmatic with persistent eosinophilia and multiple peripheral pulmonary nodules. Biopsy of these nodules was consistent with a diagnosis of angiolymphoid hyperplasia with eosinophilia (ALHE). ALHE is a rare condition that usually affects women and commonly affects subcutaneous tissues of head and neck. Only a handful of cases have reported pulmonary involvement. To our knowledge, this is the first case of pulmonary ALHE that has been treated with benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, which resulted in improvement in symptoms as well as airway and blood eosinophilia and had a modest effect on the size of the pulmonary nodules. We also highlight a novel imaging finding of beading and focal nodular dilation of sub-segmental branches of pulmonary arteries, which could reflect proliferation of small-caliber vessels and hyperplastic endothelial lining seen on histopathology.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".