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Record W3197305134 · doi:10.1016/j.cub.2021.08.016

Energy compensation and adiposity in humans

2021· article· en· W3197305134 on OpenAlexaff
Vincent Careau, Lewis G. Halsey, Herman Pontzer, Philip N. Ainslie, Lene Frost Andersen, Liam Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stéphane Blanc, A. Bonomi, Carlijn V. C. Bouten, Maciej S. Buchowski, Nancy F. Butte, Stefan Gerardus Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter T. Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine Christine Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert Ojiambo, Kirsi H. Pietiläinen, Yannis Pitsiladis, Jacob Plange‐Rhule, Guy Plasqui, Ross L. Prentice, Roberto Rabinovich, Susan B. Racette, David A. Raichlen, Éric Ravussin, John J. Reilly, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy‐Alford, Cornelia Loechl, Amy Luke, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, William W. Wong, Yosuke Yamada, John R. Speakman

Bibliographic record

VenueCurrent Biology · 2021
Typearticle
Languageen
FieldMedicine
TopicObesity, Physical Activity, Diet
Canadian institutionsUniversity of Ottawa
FundersNational Center for Advancing Translational SciencesNational Center for Research ResourcesNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteNational Center for Chronic Disease Prevention and Health PromotionNational Institute on AgingNational Cancer InstituteNational Institute on Alcohol Abuse and AlcoholismNovo Nordisk FondenNational Science FoundationNational Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentInternational Atomic Energy AgencyChinese Academy of Sciences
KeywordsBiologyEnergy (signal processing)Energy metabolismEvolutionary biologyEndocrinologyStatistics

Abstract

fetched live from OpenAlex

This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response-energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories we burn from additional activity translates into extra calories burned that day. Moreover, the degree of energy compensation varied considerably between people of different body compositions. This association between compensation and adiposity could be due to among-individual differences in compensation: people who compensate more may be more likely to accumulate body fat. Alternatively, the process might occur within individuals: as we get fatter, our body might compensate more strongly for the calories burned during activity, making losing fat progressively more difficult. Determining the causality of the relationship between energy compensation and adiposity will be key to improving public health strategies regarding obesity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.317
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations126
Published2021
Admission routes1
Has abstractyes

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Same venueCurrent BiologySame topicObesity, Physical Activity, DietFrench-language works237,207