Is Also the Patient Ready for Switching from Intravenous to Subcutaneous Biologics?
Bibliographic record
Abstract
We read with great interest the paper by Vermeire et al., confirming the efficacy and safety of a novel vedolizumab subcutaneous [SC] formulation in Crohn’s disease [CD].1 Most existing data focus on the medical aspects of switching to SC formulations.1,2 The role of the patient remains underexposed, although it is one of the key factors in the switching process. In this regard, the PREVIEW trial in our centre evaluated the willingness to switch from intravenous [IV] to SC therapy in patients with inflammatory bowel disease [IBD]. A questionnaire was proposed to all patients treated with IV therapy [CT-P13 and vedolizumab] for at least 6 weeks between December 1, 2020 until February 28, 2021 [before to the market introduction of SC alternatives]. All patients were educated about the upcoming SC alternatives, the new care pathway, and the questions that would be addressed in the survey. From...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".