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Record W3198880734 · doi:10.1038/s41408-021-00544-x

A phase 2 study of carfilzomib, cyclophosphamide and dexamethasone as frontline treatment for transplant-eligible MM with high-risk features (SGH-MM1)

2021· letter· en· W3198880734 on OpenAlexaff
Yunxin Chen, Sathish Gopalakrishnan, Melissa Ooi, Rehena Sultana, Li Hui Lim, Nicholas F. Grigoropoulos, Shin Yeu Ong, Mingge Xu, Ee Mei Teh, Melinda Si Yun Tan, Lawrence Cheng Kiat Ng, Yuh Shan Lee, Colin Phipps, Francesca Lorraine W. Y. Lim, William Ying Khee Hwang, Wee Joo Chng, Yeow Tee Goh, Chandramouli Nagarajan

Bibliographic record

VenueBlood Cancer Journal · 2021
Typeletter
Languageen
FieldMedicine
TopicMultiple Myeloma Research and Treatments
Canadian institutionsHealth Sciences North
FundersSingapore General HospitalNational University of SingaporeOnyx PharmaceuticalsDuke-NUS Medical School
KeywordsCarfilzomibDexamethasoneMedicineCyclophosphamideInternal medicinePhase (matter)OncologyIntensive care medicineChemotherapyLenalidomideChemistry

Abstract

fetched live from OpenAlex

10.1038/s41408-021-00544-x

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.518
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.333
Teacher spread0.307 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2021
Admission routes1
Has abstractyes

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