Comparison between the Efficacy of 5% Imiquimod Cream and Intralesional Triamcinolone Acetonide in the Prevention of Recurrence of Excised Ear Keloid: A Prospective Randomized Study
Bibliographic record
Abstract
ackground: Ear keloid scars represents an abnormal, exaggerated healing response after skin injury. In addition to cosmetic concern, scars may cause pain, pruritus, or contractures. Nowadays, topical therapies have increased because they are easy to use, comfortable, and non-invasive. The 5% imiquimod cream has been reported as effective to prevent the recurrence of ear keloid after surgical excision. Objective: To evaluate the efficacy of 5% imiquimod cream in decreasing the recurrence rate of keloid after surgical excision, when compared with triamcinolone acetonide injection. Materials and Methods: Thirty patients, which included 6.67% male and 93.33% female, enrolled in a prospective-randomized study. Sixteen patients were informed to use triamcinolone injection (10 mg/mL) and 14 patients were informed to apply 5% imiquimod cream (nightly every other day) for 12 weeks after the ear keloid was excised and the stitches removed. Results: The 30 patients were examined of recurrence of ear keloids on their ears for 48 weeks after surgical excision. The overall mean of Vancouver Scar Scale at one year for evaluating the effectiveness of imiquimod to decrease recurrence rate when compared with triamcinolone acetonide injection showed at 6.50 and 4.25 respectively. The patient satisfaction was slightly higher in triamcinolone group. However, the two outcomes, the Vancouver Scar Scale (p=0.389) and the patient satisfaction (p=0.833), were not statistically significant. No serious local and systemic adverse event was detected in either groups of patients. Conclusion: Treatment of surgical excision ear keloids with triamcinolone acetonide injection might be a better selection as compared to imiquimod cream for effectiveness in term of lower recurrence rate and higher patient satisfaction. A limitation of the present study is the number of the patients. Keywords: Keloid, Imiquimod, Triamcinolone acetate, Recurrence of ear keloid
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.003 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".