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Record W3199546106 · doi:10.1016/s1474-4422(21)00242-8

Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial

2021· letter· en· W3199546106 on OpenAlexaff
Merit Cudkowicz, Angela Genge, Nicholas J. Maragakis, Susanne Petri, Leonard van den Berg, Valtteri V. Aho, Toni Sarapohja, Mikko Kuoppamäki, Chris Garratt, Ammar Al‐Chalabi, Matthew C. Kiernan, Susan Mathers, Robert D. Henderson, Merrilee Needham, David Schultz, Wolfgang N. Löscher, Nenad Mitrović, Jakob Rath, Philip Van Damme, Jan De Bleecker, Stéphanie Delstanche, Wendy Johnston, Lorne Zinman, Colleen O’Connell, Geneviève Matte, Annie Dionne, Lawrence Korngut, John Turnbull, Hannu Laaksovirta, Manu Jokela, Tero Tapiola, Marie‐Hélène Soriani, Philippe Couratier, William Camu, Philippe Corcia, Albert C. Ludolph, Julian Großkreutz, Thomas Meyer, Matthias Boentert, Berthold Schrank, Johannes Prudlo, Robert Untucht, Orla Hardiman, Gabriele Siciliano, Adriano Chiò, Letizia Mazzini, Maurizio Inghilleri, Claudia Caponnetto, Gabriele Mora, Jesús S. Mora Pardina, Eva Farrero Muñoz, Juan F. Vázquez‐Costa, Eduardo Agüera, Luís Varona, Peter Andersen, Caroline Ingre, Rune Johansson, Aleksandar Radunović, Carolyn Young, Suma Babu, Aziz Shaibani, Nathan P. Staff, Tuan Vu, Michael H. Rivner, Stephen N. Scelsa, Kumaraswamy Sivakumar, Waqar Waheed, Daragh Heitzman, Sandeep Rana, Gary L. Pattee, Senda Ajroud‐Driss, Elham Bayat, Edward J. Kasarskis, Dale J. Lange, Michael A. Elliott, Brent T. Harris, Kevin J. Felice, Michael Pulley, Justin Kwan, M. Brown, John Ravits, Matthew Burford, Chafic Karam, Timothy M. Miller, Jinsy Andrews, Todd Levine, Eduardo Locatelli, James Wymer, Richard Bedlack, Dominic Fee, Namita Goyal, Björn Oskarsson, Leo McCluskey, James B. Caress, Michael D. Weiss, Adam Quick, Mark B. Bromberg, David Lacomis, Stephen A. Goutman, Kourosh Rezania, Gaurav Guliani, Kimberly Goslin, Jonathan Katz

Bibliographic record

VenueThe Lancet Neurology · 2021
Typeletter
Languageen
FieldMedicine
TopicAmyotrophic Lateral Sclerosis Research
Canadian institutionsMontreal Neurological Institute and Hospital
FundersNational Institute for Health and Care ResearchOMRON Corporation
KeywordsMedicineAmyotrophic lateral sclerosisClinical endpointPlaceboLevosimendanAdverse effectPopulationInternal medicinePhysical therapyRiluzoleClinical trialHeart failurePathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.252
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0040.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.005
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.085
GPT teacher head0.340
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations19
Published2021
Admission routes1
Has abstractno

Explore more

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