In vitro digestion of folate in yolk and granule fraction as tested in a dynamic, computer-controlled model of stomach and small intestine
Bibliographic record
Abstract
In our previous studies, we showed that egg yolk fractionation by centrifugation can lead to complete separation of folate in granule fraction of egg yolk which has two folds more protein than egg yolk. Folate in egg yolk presents in the form of 5-methyltetrahydrofolate (5MTHF), a predominant type of highly available form of folate. However, evidence is lacking as to the bioaccessibility of the 5MTHF in granule fraction separated through water-based fractionation technique. Thereby, a dynamic and computer-controlled gastro-small intestinal system was used to study and compare the distribution of 5MTHF throughout intestinal compartments during digestion of egg yolk and granule fraction in their native form. As granule fraction of yolk composed of higher protein content compare to egg yolk, the dialysis profile of protein change during the process for yolk and granule was determined. The 5MTHF was stable during digestion with average recoveries of 58% and 42% in granule and yolk, respectively. The present work is the first to present data on the bioaccessibility of natural folate from egg yolk granule and shows the potential of egg yolk granules as «natural» delivery system of 5MTHF.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".