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Record W3206919399 · doi:10.1038/s41586-021-04008-x

Ethics of DNA research on human remains: five globally applicable guidelines

2021· article· en· W3206919399 on OpenAlexaff
Songül Alpaslan-Roodenberg, David W. Anthony, Hiba Babiker, Eszter Bánffy, Thomas Booth, Patricia Capone, Arati Deshpande-Mukherjee, Stefanie Eisenmann, Lars Fehren‐Schmitz, Michael D. Frachetti, Ricardo Fujita, Catherine J. Frieman, Qiaomei Fu, Victoria E. Gibbon, Wolfgang Haak, Mateja Hajdinjak, Kerstin P. Hofmann, Brian Holguin, Takeshi Inomata, Hideaki Kanzawa‐Kiriyama, William F. Keegan, Janet Kelso, Johannes Krause, Kumaresan Ganesan, Chapurukha M. Kusimba, Sibel Kusimba, Carles Lalueza‐Fox, Bastien Llamas, Scott MacEachern, Swapan Mallick, Hirofumi Matsumura, Ana Y. Morales‐Arce, Giedrė Motuzaitė Matuzevičiūtė, Veena Mushrif‐Tripathy, Nathan Nakatsuka, Rodrigo Nores, Christine Ogola, Mercedes Okumura, Nick Patterson, Ron Pinhasi, Samayamantri P. R. Prasad, Mary E. Prendergast, José Luis Punzo, David Reich, Rikai Sawafuji, Elizabeth Sawchuk, Stephan Schiffels, Jakob Sedig, Светлана Шнайдер, Kendra Sirak, Pontus Skoglund, Viviane Slon, Meradeth Snow, Marie Soressi, Matthew Spriggs, Philipp W. Stockhammer, Anna Szécsényi‐Nagy, Kumarasamy Thangaraj, Vera Tiesler, Raymond Tobler, Chuan‐Chao Wang, Christina Warinner, S.G. Yasawardene, Muhammad Zahir

Bibliographic record

VenueNature · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicForensic and Genetic Research
Canadian institutionsUniversity of Alberta
FundersMax-Planck-GesellschaftFrancis Crick InstituteMagyar Tudományos AkadémiaFundação de Amparo à Pesquisa do Estado de São PauloNational Research FoundationScience and Engineering Research BoardCancer Research UKNederlandse Organisatie voor Wetenschappelijk OnderzoekWellcome TrustConselho Nacional de Desenvolvimento Científico e TecnológicoNational Institute of General Medical SciencesNational Geographic SocietyJohn Templeton FoundationMedical Research CouncilHoward Hughes Medical Institute
KeywordsCommitEngineering ethicsResearch ethicsStakeholderPlan (archaeology)Political scienceWork (physics)Public relationsComputer scienceHistoryEngineering

Abstract

fetched live from OpenAlex

We are a group of archaeologists, anthropologists, curators and geneticists representing diverse global communities and 31 countries. All of us met in a virtual workshop dedicated to ethics in ancient DNA research held in November 2020. There was widespread agreement that globally applicable ethical guidelines are needed, but that recent recommendations grounded in discussion about research on human remains from North America are not always generalizable worldwide. Here we propose the following globally applicable guidelines, taking into consideration diverse contexts. These hold that: (1) researchers must ensure that all regulations were followed in the places where they work and from which the human remains derived; (2) researchers must prepare a detailed plan prior to beginning any study; (3) researchers must minimize damage to human remains; (4) researchers must ensure that data are made available following publication to allow critical re-examination of scientific findings; and (5) researchers must engage with other stakeholders from the beginning of a study and ensure respect and sensitivity to stakeholder perspectives. We commit to adhering to these guidelines and expect they will promote a high ethical standard in DNA research on human remains going forward.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.249
metaresearch head score (Gemma)0.192
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.971
Threshold uncertainty score0.926

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2490.192
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0030.004
Bibliometrics0.0050.005
Science and technology studies0.0070.020
Scholarly communication0.0170.008
Open science0.0090.014
Research integrity0.0290.026
Insufficient payload (model declined to judge)0.0030.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.107
GPT teacher head0.487
Teacher spread0.380 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designTheoretical or conceptual
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations139
Published2021
Admission routes1
Has abstractyes

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