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Record W3209252785 · doi:10.29309/tpmj/2021.28.11.6400

Role of diacerein in osteoarthritis.

2021· article· en· W3209252785 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueThe Professional Medical Journal · 2021
Typearticle
Languageen
FieldMedicine
TopicOsteoarthritis Treatment and Mechanisms
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineWOMACOsteoarthritisVisual analogue scaleInternal medicineDiarrheaRetrospective cohort studySurgeryAlternative medicine

Abstract

fetched live from OpenAlex

Objectives: To evaluate the role of Diacerein among patients with OA. Study Design: Retrospective Case Series. Setting: Mayo Hospital, Lahore. Period: April 2020 to September 2020. Material & Methods: The study was conducted among forty patients with OA (grade II to IV according to ACR criteria) at Department of Rheumatology (EMW), Mayo Hospital, Lahore. Baseline WOMAC (Western Ontario and McMaster Universities Arthritis Index) and VAS (Visual Analogue Scale) was noted. Diacerine, 100mg in bd (twice a day) dose was given for 6 months. After 6 months, WOMAC and VAS were noted and %age improvement was calculated. Results: The mean WOMAC at presentation was 48.78+6.42 and after treatment was 36.20+20 (p<0.05). The mean VAS before and after treatment was 5.88+1.20 and 3.58+3.22, respectively (p<0.05). A 20% improvement was seen among 40% patients. The efficacy of the drug was labeled as yes in 40% patients. One (2.5%) patients suffered from diarrhea, and one (2.5%) patient had raised LFTs after treatment. Conclusion: Diacerine significantly improves the mean WOMAC and VAS score after 6 months of therapy. The efficacy is also high. So, it can be considered as an alternative drug among symptomatic patients with OA in whom the symptoms do not improve after conventional analgesics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.877
Threshold uncertainty score0.998

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.287
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it