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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

2021· article· en· 723 citations· W3209735640 on OpenAlex· 10.1016/j.immuni.2021.11.001

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.038
GPT teacher head0.320
Teacher spread
0.282 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Immunity
Topic
SARS-CoV-2 and COVID-19 Research
Field
Medicine
Canadian institutions
Acuitas Therapeutics (Canada)
Funders
National Institute of Allergy and Infectious DiseasesIcahn School of Medicine at Mount SinaiNational Cancer InstituteUniversity of PennsylvaniaChildren's Hospital of Philadelphia
Keywords
AdjuvantGerminal centerImmune systemBiologyCytokineB cellVaccinationLipid AImmunologyCellVirologyAntibodyLipopolysaccharideBiochemistry
Has abstract in OpenAlex
no