S1132 Improvement in Survival Scores After Ursodiol Use Among Ursodiol Responders vs. Non-Responders in a Community Setting – Newcastle Model and ALBI Score
Bibliographic record
Abstract
Introduction: Primary biliary cholangitis (PBC) is a chronic autoimmune disorder characterized by portal inflammation and intrahepatic biliary duct destruction. Ursodiol is the first-line treatment for many patients with PBC. Response to ursodiol has been effectively measured by Toronto criteria in previous studies. The primary aim of this study was to assess for the improvement of recently used prognostic scores after ursodiol use among ursodiol responders vs non-responders. The secondary aim was to identify non-responders early to potentially prevent undesired liver decompensation events. Methods: A retrospective cohort study was conducted at Liver Associates of Texas Hepatology outpatient clinic in Houston, Texas. All patients diagnosed with PBC from January 2018-May 2021 were included. Lab and Fibroscan results before and 1 year after starting ursodiol in these patients were collected from their records. Response to Ursodiol was measured using the Toronto criteria [alkaline phosphatase (ALP)≤1.67*ULN are responders and ALP >1.67*ULN are non-responders]. Continuous variables were compared with either the Student’s T-test or Wilcoxon Rank-sum test. Chi-square test, Fisher’s exact test and logistic regression were used for categorical variables. Significance level was set at 5%. Results: Ursodiol response data was available for 111/136 patients with PBC. 65/111 (58.6%) were ursodiol responders and 46/111 (41.4%) were ursodiol non-responders. Majority of the patients were female and there was no significant difference in gender and race/ethnicity distribution. Age, ALP, and APRI score were significantly different among two groups. AST/ALT ratio [p=0.037] and Newcastle Model score [p=0.023] were significantly different after ursodiol use. Newcastle model score was significantly different among ursodiol responders after ursodiol use [p=0.012 vs 0.780]. Non-response to ursodiol is significantly negatively correlated with the Newcastle model score [OR=0.58, p=0.036] and significantly positively correlated with the ALBI score [OR=3.70, p=0.009] in a multiple logistic regression model. Conclusion: Non-responders had a 42% lower Newcastle model score compared to responders after ursodiol use. The ALBI score increased 3.7 times among non-responders compared to responders after ursodiol use. Hence, there is an improvement in Newcastle model score and ALBI score after ursodiol use among responders and can be used to identify non-responders early.Table 1.: Sociodemographic variables in Ursodiol responders vs non-responders among PBC patients
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".