P-360 Is occupational exposure to polycyclic aromatic hydrocarbons associated with prostate cancer risk? Results from PROtEuS, Montreal, Canada
Bibliographic record
Abstract
Introduction Polycyclic aromatic hydrocarbons (PAHs) have been shown to have endocrine-disrupting effects. Exposure could be carcinogenic to the prostate, a hormone-dependent organ. Objective To examine the association between lifetime occupational exposure to PAHs and prostate cancer risk. Methods Face-to-face interviews elicited detailed work histories for 1,937 histologically confirmed prostate cancer cases (524 aggressive) and 1,994 controls from Montreal, Canada. Industrial hygienists applied the hybrid expert assessment approach to assign concentration, frequency and certainty of exposure to benzo(a)pyrene, PAHs from different sources (wood, coal, petroleum, other sources) and PAHs from any source. Odds ratios (ORs) adjusted for age, ancestry, education, lifestyle and occupational factors, and their 95% confidence intervals (CI), were estimated using unconditional logistic regression. Results After restriction to probable and definite exposure, and application of a 5-year lag, no clear association was observed between exposure to PAHs and overall prostate cancer risk, although a weak positive dose-response pattern emerged for total duration of exposure to PAHs from wood (OR=1.06; 95%CI 0.95 to 1.18, per 5-year increment). Men in the upper tertile of cumulative exposure to these PAHs showed an elevated OR of 1.54 (95%CI 0.60 to 3.92), predominantly reflecting the non-aggressive form of the tumour (OR=1.74; OR=0.67 to 4.56). Nevertheless, exposure to PAHs from wood occurring at least 10 years before the index date was associated with some elevated risks of high-grade tumours (OR=1.54, 95%CI 0.70–3.39). Similar results were found in sensitivity analyses, including those restricted to controls recently screened for prostate cancer or in those prioritizing the Gleason score ascertained from prostatectomy over that from biopsy. Conclusion Only a handful of small studies have used detailed exposure assessment protocols to study the role of PAHs in prostate cancer risk. Our findings provide some limited evidence that exposure to PAHs from wood increases the risk of prostate cancer.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".