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Record W3211017459 · doi:10.1016/j.bpsc.2021.10.011

Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes

2021· article· en· W3211017459 on OpenAlexafffund
Quentin Le Grand, Claudia L. Satizábal, Muralidharan Sargurupremraj, Aniket Mishra, Aïcha Soumaré, Alexandre Laurent, Fabrice Crivello, Ami Tsuchida, Jean Shin, Mélissa Macalli, Baljeet Singh, Alexa Beiser, Charles DeCarli, Evan Fletcher, Tomáš Paus, Mark Lathrop, Hieab H.H. Adams, Joshua C. Bis, Sudha Seshadri, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette

Bibliographic record

VenueBiological Psychiatry Cognitive Neuroscience and Neuroimaging · 2021
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsMcGill UniversityMcGill Genome CentreUniversité de MontréalCentre Hospitalier Universitaire Sainte-JustineUniversity of TorontoSickKids FoundationHospital for Sick Children
FundersH2020 European Research CouncilNational Institute of Neurological Disorders and StrokeNational Heart, Lung, and Blood InstituteNational Institute on AgingHorizon 2020National Health and Medical Research CouncilMedical Research CouncilNational Institutes of HealthEuropean CommissionInstitute Pasteur De LilleSanofiFondation Claude PompidouCanadian Institutes of Health ResearchMutuelle Générale de l'Education NationaleEuropean Research CouncilUniversité de BordeauxZonMwInstitut National de la Santé et de la Recherche MédicaleHORIZON EUROPE Framework ProgrammeAgence Nationale de la RechercheFondation LeducqBundesministerium für Wissenschaft, Forschung und WirtschaftFondation pour la Recherche MédicaleMcGill UniversityFondation de FranceBundesministerium für Bildung und ForschungBoston UniversityAlzheimer's AssociationDevelopment of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
KeywordsNeurodegenerationNeurosciencePathologicalBiologyBrain developmentPsychologyMedicinePathologyDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.181
Threshold uncertainty score0.622

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.077
GPT teacher head0.385
Teacher spread0.308 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2021
Admission routes2
Has abstractno

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