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Record W3211017459 · doi:10.1016/j.bpsc.2021.10.011

Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes

2021· article· en· W3211017459 on OpenAlexafffund
Quentin Le Grand, Claudia L. Satizábal, Muralidharan Sargurupremraj, Aniket Mishra, Aïcha Soumaré, Alexandre Laurent, Fabrice Crivello, Ami Tsuchida, Jean Shin, Mélissa Macalli, Baljeet Singh, Alexa Beiser, Charles DeCarli, Evan Fletcher, Tomáš Paus, Mark Lathrop, Hieab H.H. Adams, Joshua C. Bis, Sudha Seshadri, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette

Bibliographic record

VenueBiological Psychiatry Cognitive Neuroscience and Neuroimaging · 2021
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsMcGill UniversityMcGill Genome CentreUniversité de MontréalCentre Hospitalier Universitaire Sainte-JustineUniversity of TorontoSickKids FoundationHospital for Sick Children
FundersH2020 European Research CouncilNational Institute of Neurological Disorders and StrokeNational Heart, Lung, and Blood InstituteNational Institute on AgingHorizon 2020National Health and Medical Research CouncilMedical Research CouncilNational Institutes of HealthEuropean CommissionInstitute Pasteur De LilleSanofiFondation Claude PompidouCanadian Institutes of Health ResearchMutuelle Générale de l'Education NationaleEuropean Research CouncilUniversité de BordeauxZonMwInstitut National de la Santé et de la Recherche MédicaleHORIZON EUROPE Framework ProgrammeAgence Nationale de la RechercheFondation LeducqBundesministerium für Wissenschaft, Forschung und WirtschaftFondation pour la Recherche MédicaleMcGill UniversityFondation de FranceBundesministerium für Bildung und ForschungBoston UniversityAlzheimer's AssociationDevelopment of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
KeywordsNeurodegenerationNeurosciencePathologicalBiologyBrain developmentPsychologyMedicinePathologyDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.077
GPT teacher head0.385
Teacher spread0.308 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2021
Admission routes2
Has abstractno

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Same venueBiological Psychiatry Cognitive Neuroscience and NeuroimagingSame topicDementia and Cognitive Impairment ResearchFrench-language works237,207