The reactome pathway knowledgebase 2022
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Abstract
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied ('dark') proteins from analyzed datasets in the context of Reactome's manually curated pathways.
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The record
- Venue
- Nucleic Acids Research
- Topic
- Bioinformatics and Genomic Networks
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of TorontoOntario Institute for Cancer Research
- Funders
- National Institute of General Medical SciencesNational Cancer InstituteNational Institutes of HealthNational Human Genome Research InstituteUniversity of TorontoEuropean Bioinformatics Institute
- Keywords
- BiologyComputational biology
- Has abstract in OpenAlex
- yes