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Record W3213899689 · doi:10.1016/s2152-2650(21)02101-7

OAB-027: Idecabtagene vicleucel (ide-cel, bb2121), a BCMA-directed CAR T-cell therapy, for the treatment of patients with relapsed and refractory multiple myeloma (RRMM): updated results from KarMMa

2021· article· en· W3213899689 on OpenAlexaff
Larry Anderson, Nina Shah, Sundar Jagannath, Jesús G. Berdeja, Sagar Lonial, Noopur Raje, David S. Siegel, Yi Lin, Philippe Moreau, Ibrahim Yakoub‐Agha, Michel Delforge, Hermann Einsele, Hartmut Goldschmidt, Katja Weisel, Michèle Cavo, Donna Reece, Alessandro Rambaldi, Anna Truppel-Hartmann, Payal Patel, Liping Huang, Timothy Campbell, Kristen Hege, Jesús F. San Miguel, Nikhil C. Munshi, Albert Oriol

Bibliographic record

VenueClinical Lymphoma Myeloma & Leukemia · 2021
Typearticle
Languageen
FieldMedicine
TopicCAR-T cell therapy research
Canadian institutionsPrincess Margaret Cancer Centre
Fundersnot available
KeywordsMedicineLenalidomidePomalidomideFludarabineInternal medicineBortezomibCarfilzomibRituximabDaratumumabRegimenMultiple myelomaRefractory (planetary science)Clinical endpointOncologyCyclophosphamideGastroenterologySurgeryClinical trialChemotherapyLymphoma

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0020.001
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.311
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2021
Admission routes1
Has abstractno

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