Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation
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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.328 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Abstract During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to be potentially hazardous to human society 1 . The recently emerged B.1.617.2/Delta variant of concern is closely associated with the COVID-19 surge that occurred in India in the spring of 2021 (ref. 2 ). However, the virological properties of B.1.617.2/Delta remain unclear. Here we show that the B.1.617.2/Delta variant is highly fusogenic and notably more pathogenic than prototypic SARS-CoV-2 in infected hamsters. The P681R mutation in the spike protein, which is highly conserved in this lineage, facilitates cleavage of the spike protein and enhances viral fusogenicity. Moreover, we demonstrate that the P681R-bearing virus exhibits higher pathogenicity compared with its parental virus. Our data suggest that the P681R mutation is a hallmark of the virological phenotype of the B.1.617.2/Delta variant and is associated with enhanced pathogenicity.
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The record
- Venue
- Nature
- Topic
- SARS-CoV-2 and COVID-19 Research
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Daiichi Sankyo EuropeStrategic International Collaborative Research ProgramCore Research for Evolutional Science and TechnologyResearch Institute for Microbial Diseases, Osaka UniversityLotte FoundationInstitute of GeneticsNational Institutes of HealthDaiichi Sankyo Foundation of Life ScienceOno Medical Research FoundationJapan Society for the Promotion of ScienceMochida Memorial Foundation for Medical and Pharmaceutical ResearchTsuchiya FoundationTakeda Science FoundationMitsubishi FoundationSumitomo FoundationTokyo Biochemical Research FoundationUniversity of TokyoJapan Agency for Medical Research and DevelopmentNational Institute of Allergy and Infectious DiseasesIchiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Keywords
- PathogenicityMutationSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakBiologyVirologyGeneticsMedicineMicrobiologyDiseaseGeneInfectious disease (medical specialty)Internal medicine
- Has abstract in OpenAlex
- yes