RETRACTED: Promotion of tumor progression by exosome transmission of circular RNA circSKA3
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Image;Duplication of/in Image;Investigation by Journal/Publisher;
- Date
- 1/16/2025 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
, circSKA3-containing exosomes potentiated tumor development and invasion that were inhibited by blocking exosome transmission. The ascites isolated from tumor-bearing mice or breast cancer patients showed high levels of circSKA3 and integrin β1. Single-cell culture and single-cell PCR showed that circSKA3 was heterogeneously expressed, the cells expressing higher levels of circSKA3 had a higher potential to form large colonies. This property was similar to c-myc, but circSKA3 expression had no correlation with c-myc levels. The effects of circSKA3 on cell migration and invasion appeared to predominate c-myc functions. By releasing circSKA3-containing exosomes to cancer cells expressing lower levels of circSKA3, the large colonies could regulate the activities of small colonies, enhancing the tumor-forming capacity of the entire population. Thus, we provide evidence that the transmission of circular RNAs in tumor-derived exosomes may allow for the maintenance of advantageous invasive sub-clones in breast cancer.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Molecular Therapy — Nucleic Acids
- Topic
- Circular RNAs in diseases
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of TorontoHealth Sciences CentreSunnybrook Health Science Centre
- Funders
- Canadian Institutes of Health ResearchSunnybrook Research Institute
- Keywords
- ExosomeMicrovesiclesIn vivoBreast cancerMetastasisCancer researchBiologyIn vitroCircular RNACancerRNAPopulationTumor progressionmicroRNAMedicineGene
- Has abstract in OpenAlex
- yes