Monoamine Oxidase Type B Inhibitors in the Treatment of Early Parkinson’s Disease
Bibliographic record
Abstract
Therapy in Parkinsons disease (PD) needs to be individualized since patients differ in symptom expression and responsiveness to pharmacotherapy. Disease-modifying drugs should be considered early in the course of the disease, but none is currently US Food and Drug Administration (FDA)-approved for this indication. Symptomatic therapies should be optimized to keep the patient independent and functioning for as long as possible. Early therapies in PD consist of dopamine agonists, monoamine oxidase type B (MAO-B) inhibitors, and, in some patients, carbidopalevodopa (depending on age and symptom severity). MAO-B inhibitors are approved by the FDA for monotherapy in treatment of early PD and as an adjunct to levodopa in advanced disease. This article focuses on the role of MAO-B enzymes in PD pathogenesis and reviews clinical evidence for the use of MAO-B inhibitors in the treatment of early PD.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".