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Record W342978127

Genome Project Standards in a New Era of Sequencing

2010· article· en· W342978127 on OpenAlexaboutno aff
Jessica B. Hostetler

Bibliographic record

VenueeScholarship (California Digital Library) · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Phylogenetic Studies
Canadian institutionsnot available
Fundersnot available
KeywordsGenomeComputational biologyComputer scienceBiologyGeneticsGene
DOInot available

Abstract

fetched live from OpenAlex

A Joint Announcement on Genome Sequence Standards Genome project standards in a new era of sequencing P. S. G. Chain 1,2,3,4,22,* , D. V. Grafham 5,* , R. S. Fulton 6 , M. G. FitzGerald 7 , J. Hostetler 8 , D. Muzny 9 , J. C. Detter 1,10 , J. Ali 11 , B.Birren 7 , D. C. Bruce 1, 10 , C. Buhay 9 , J. R. Cole 3,4 , Y. Ding 9 , S. Dugan 9 , D. Field 12 , G. M. Garrity 3,4 , R. Gibbs 9 , T. Graves 6 , C. S. Han 1, 10 , S. H. Harrison 3 , S. Highlander 9 , P. Hugenholtz 1 , H. M. Khouri 13 , C. D. Kodira 7,23 , E. Kolker 14,15 , N. C. Kyrpides 1 , D. Lang 1,2 , A. Lapidus 1 , S. A. Malfatti 1,2 , V. Markowitz 16 , T. Metha 7 , K. E. Nelson 8 , J. Parkhill 5 , S. Pitluck 1 , X. Qin 9 , T. D. Read 17 , J. Schmutz 18 , S. Sozhamannan 19 , R. Strausberg 8 , G. Sutton 8 , N. R. Thomson 5 , J. M. Tiedje 3,4 , G. Weinstock 6 , A. Wollam 6 , and the entire GSC 20 and HMP Jumpstart 21 consortia. U.S. Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, California 94550, USA Microbiology & Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824, USA The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02141, USA J. Craig Venter Institute, Rockville, Maryland 20850, USA Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada Natural Environmental Research Council Centre for Ecology and Hydrology, Oxford, Oxfordshire OX1 3SR, UK National Center for Biotechnology Information, National Library of Medicine, Rockville, Maryland 20850, USA Seattle Children’s Hospital and Research Institute, Seattle, Washington 98101, USA Biomedical & Health Informatics Division, MEBI, University of Washington School of Medicine, Seattle, Washington 98195, USA Biological Data Management and Technology Center, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA Emory GRA Genomics Core, Emory University School of Medicine, Atlanta, Georgia 30322, USA HudsonAlpha Genome Sequencing Center, HudsonAlpha Institute, Huntsville, Alabama 35806, USA Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring, Maryland 20910, USA Genomic Standards Consortium Human Microbiome Project Jumpstart Consortium Current address: Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA Current address: 454 Life Sciences, Branford, Connecticut 06405, USA *Address correspondence to Patrick Chain (pchain@lanl.gov) and Darren Grafham (dg1@sanger.ac.uk)

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.154
metaresearch head score (Gemma)0.147
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.846
Threshold uncertainty score0.814

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1540.147
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0060.010
Science and technology studies0.0030.007
Scholarly communication0.0150.020
Open science0.0060.010
Research integrity0.0090.022
Insufficient payload (model declined to judge)0.0050.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.229
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2010
Admission routes1
Has abstractyes

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