Effects of high salt diet on NF‐KB and CREB DNA binding activity in heart, kidney and hypothalamus of SHR
Bibliographic record
Abstract
In Dahl S or SHR on high salt diet, activation of NF‐κB contributes to cardiac hypertrophy and renal damage, which may be offset by activation of CREB. The brain RAAS mediates the salt‐induced hypertension, possibly by NF‐κB in the PVN. We assessed effects of high salt diet on DNA‐binding activity of NF‐κB and CREB in the heart, kidney and PVN of WKY rats and SHR on high (8%) or reg (0.6%) salt diet for 2 or 4 weeks (n=6). NF‐κB and CREB DNA binding activity were studied by electrophoretic mobility shift assay. In WKY, high salt only increased CREB DNA binding activity in the LV and NFκB in the PVN. In SHR, high salt increased NF‐κB DNA‐binding activity in the heart and kidney, but decreased CREB binding activity in the heart, kidney, and the PVN. Conclusion High salt causes an inverse relationship between NF‐κB and CREB in the LV, kidney and PVN which may contribute to salt induced sympathetic hyperactivity, LV and renal hypertrophy in SHR.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".