Apin participates in establishment of the incompletely‐differentiated junctional epithelium around teeth
Bibliographic record
Abstract
A novel gene, Apin (Odam), belonging to a gene cluster encoding for proteins involved in the regulation of mineralization, was cloned in our laboratory. Initial studies suggested that Apin might mediate adhesion of the portion of the gingiva that attaches to the tooth surface (junctional epithelium; JE). It is also expressed in many epithelial cancers, including odontogenic tumors. Purpose To validate the implication of Apin in JE formation by comparing its distribution in normal and regenerating gingiva. Materials and methods: Gingivectomies were done on the maxillae of adult rats. The contralateral maxilla was left intact as a control. Animals were sacrificed on days 0‐7 after surgery and maxillae were processed for paraffin embedding and immunolabeling for Apin. Results In control samples, Apin was localized among cells of the JE and along its interface with the tooth. No labeling was seen in the residual gingiva at day 0. Over time, Apin labeling reappeared in the regenerating JE emerging from the gingiva. By day 7, the labeling pattern was similar to controls. Conclusion The interfacial localization of Apin suggests that it plays a role in adhesion. Its presence among cells of the JE, an incompletely differentiated epithelium, and its expression in epithelial tumors indicates that Apin may also be implicated in other cellular activities such as differentiation. Support by CIHR and Department of Foreign Affairs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".