Strain Specific Persistent Suppression of Visceral Pain Perception After Recovery From a Bout of Colitis
Bibliographic record
Abstract
Visceral pain is often experienced by patients with GI inflammation, and some studies suggest that such pain can persist after resolution of inflammation. Colitis was induced in male Wistar and Sprague‐Dawley ( SD ) rats via intrarectal administration of dinitrobenzene sulfonic acid (DNBS) in 50% ethanol, controls received saline only. At day 15, under general anesthesia, a balloon was inserted into the colon and distended (colo‐rectal distention; CRD), heart rate was recorded continuously. Cardioautonomic responses to CRD were analyzed and expressed as % change from the pre‐CRD heart rate. Colonic injury and inflammation were examined histologically and by measurement of tissue myeloperoxidase activity. By 15 days following DNBS administration, colitis had resolved. CRD caused a significant visceral pain response (bradycardia) in both strains of control rats. However, Wistar rats showed a significant suppression of pain response to CRD, whereas the response in SD rats remained the same after colitis. There was no difference in colonic compliance between control and DNBS groups or the two strains. Our results provide evidence of a strain‐dependent alteration in the pain response to CRD that persists after resolution of colitis, likely due to changes in autonomic sensory function induced by inflammation. Our results are consistent with the variability in pain perception seen in patients with GI inflammation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".