Interaction of Long-Chain Alcohol with Dry Yeast, Cholesterol, and Sea Firefly Luciferase
Bibliographic record
Abstract
Background: A hand sanitizer containing alcohol, usually ethanol or isopropanol, is typically used for disinfection, but given that cholesterol is one of the main components of virus envelopes, long-chain alcohol may be more effective. To better understand the potential disinfection activity of long-chain alcohols, we studied their interactions with dry yeast, cholesterol, and sea firefly luciferase. Methods and Results: We measured, at 30oC and 39oC, the minimum inhibition concentration (MIC) of dry yeast fermentation and the stability of cholesterol and sea firefly luciferase with alcohols, diols, cetyltrimethylammonium chloride, and stearyltrimethylammonium chloride. The MIC decreased with the chain length at C≤12 for dry yeast and cholesterol with alcohol at 30oC. At C13 and higher, the cut-off region was observed. At 39oC, the cut-off region shifted to C15 and higher. The reduction of MIC was measured with the diol or sea firefly luciferase at C≤14. Conclusion: The presence of the cut-off region is suggested to be related to whether the alcohol is in the liquid state. For the liquid alcohol, the longer the chain length, the lower the MIC. This suggests a potential disinfection activity of long-chain alcohol.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".