MétaCan
Menu
Back to cohort
Record W4200135346 · doi:10.1016/s0140-6736(21)02753-7

Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial

2021· article· en· W4200135346 on OpenAlexaff
Scott A. Halperin, Lingyun Ye, Donna MacKinnon‐Cameron, Bruce R. Smith, Pedro Cahn, Guillermo M. Ruiz‐Palacios, Aamer Ikram, Fernando Laņas, M. Lourdes Guerrero, Sergio Raúl Muñoz Navarro, Omar Sued, Dmitry Lioznov, Vitalina Dzutseva, Ghazala Parveen, Fengcai Zhu, Laura Leppan, Joanne M. Langley, Luis Barreto, Jin-Bo Gou, Tao Zhu, Helen Mao, Luc Gagnon, Steven-Phay Tran, S. Khan, Amalia Guadalupe Becerra Aquino, Edgar Eduardo Saldaña Montemayor, Norma E. Rivera-Martínez, Víctor Casildo Bohórquez López, Jesus Abraham Simón Campos, Felipe de Jesús Pineda Cárdenas, Wei Chen, Lihua Hou, Zhe Zhang, Gonzalo Corral, Eduardo López, Ricardo Teijeiro, María Fernanda Alzogaray, Cesar Javier Zaidman, Gustavo Lopardo, Bernardo Goecke, Rosa María Feijooó Seoane, Sayed Faisal Mahmood, Ejaz Ahmed Khan, Jayed Akram, Salma Abbas, Naseem Salahuddin, E. G. Rozhkova, Tatyana Zubkova

Bibliographic record

VenueThe Lancet · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicVirus-based gene therapy research
Canadian institutionsNova Scotia Health AuthorityDalhousie University
FundersBeijing Institute of Technology
KeywordsImmunogenicityInterimInterim analysisVirologyMedicineCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Recombinant DNAVector (molecular biology)2019-20 coronavirus outbreakClinical trialImmunologyInternal medicineBiologyImmune systemOutbreakGeography

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.027

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.005
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.004
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.000
Research integrity0.0030.003
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.064
GPT teacher head0.373
Teacher spread0.309 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations237
Published2021
Admission routes1
Has abstractno

Explore more

Same venueThe LancetSame topicVirus-based gene therapy researchFrench-language works237,207