Corrigendum to: Safety of ixekizumab in adult patients with plaque psoriasis, psoriatic arthritis and axial spondyloarthritis: data from 21 clinical trials
Bibliographic record
Abstract
Rheumatology 2020;59:3835–3845 doi: 10.1093/rheumatology/keaa189 In the originally published version of this manuscript, there were errors in the rate of latent TB reported for IXE PsA population. These errors have been corrected online. Specifically, the following changes have been made: The definition of latent tuberculosis in the methods section has been corrected to: ‘Latent tuberculosis (TB) infection was based by either latent tuberculosis or a positive result on any of the following annual tests: tuberculin skin test, interferon-gamma release assay, or mycobacterium tuberculosis complex test.’ Discontinuation in the PsA population in the results section has been corrected to: ‘The main causes of discontinuation in the PsA population were latent TB (either latent tuberculosis or a positive result on any of the following annual tests: tuberculin skin test, interferon-gamma release assay, or mycobacterium tuberculosis complex test; n = 20, IR = 0.8 per 100 PY), ISR (n = 5, IR 0.2 per 100 PY) and pneumonia (n = 3, IR 0.1 per 100 PY).’ Table 3, line ‘˜Latent tuberculosis infections’, column ‘˜Pooled PsA IXE’ has been corrected to: n (%) 35(2.5), IR 1.6, and 95% CI 1.1, 2.2. Table 3, footnote ‘a’ has been corrected to: ‘Includes either latent tuberculosis or a positive result on any of the following annual tests: tuberculin skin test, interferon-gamma release assay, or mycobacterium tuberculosis complex test.’ A sentence in the results section has been corrected to: ‘Latent TB infection was reported by105 patients with PsO (IR 0.6 per 100 PY), 35 patients with PsA (IR 1.6 per 100 PY), and 1 patient with axSpA (IR 0.1 per 100 PY).’ A sentence in the discussion section has been corrected to: ‘Overall, annual TB testing revealed 141 patients across populations (PsO n = 105, PsA n =35, axSpA n = 1) with latent TB infections.’ The following sentence has been removed from the discussion section: ‘No cases of positive TB seroconversion were reported in the axSpA population.’ And another sentence in the discussion section has been corrected to: ‘Positive TB tests led to discontinuation (which was protocol-specified for a portion of the studies) for 67 patients with PsO and 20 patients with PsA. However, no confirmed cases of TB reactivation occurred in the ixekizumab clinical trials, including patients with latent or previously treated Mycobacterium tuberculosis infection.’
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.080 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.004 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.194 | 0.064 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".