Laser Photobiomodulation of the Induratio Penis Plastica or La Peyronie's Syndrome
Bibliographic record
Abstract
Background: Since 1980, laser therapy has been proposed with success in the treatment of the Induratio Penis Plastica (IPP), also called La Peyronie's Syndrome, but still few physicians use it. Objective: We would like to investigate the clinical effects of using more laser sequentially in each session, in the treatment of chronic IPP. We used high levels of energy, watts rather than milliwatts, reducing the duration of each application, and the number of the cycles in total. Materials and methods: Laser wavelengths used for photobiomodulation (PBM) were 808, 1064, and 10,600 nm. Taking into account the clinical aspect of the lesion being treated, the specific dosage for each patient was determined. Penis echography established the exact localization and extension of the pathologic fibrous tissue as plaque, nodules, and ring. From 2012 to 2019, we treated 41 patients, 35–65 years old, who were selected using the same criteria: inflammatory signs present since ≥12 months, negative results with two other types of physical therapy, and exclusion of surgical cases. Results: Echographic test was repeated 1 month after the end of the treatment, for the evaluation of the results. Further parameters of results evaluation were presence/absence of pain, inflammation, recurvation, and functional limitation. The control was done comparing similar cases not treated with laser, selected with random criteria. Discussion and conclusions: Results were positive in a high percentage of patients, the majority after one cycle of treatment, and follow-up was positive after 2 years. The sequential use of more laser with wavelengths listed above gave better results than the wavelengths used up until the year 2000, in our previous experience. We need fewer cycles to obtain positive results, and follow-up improved significantly.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".