Alternative Treatments of Postpartum Uterine Diseases in Dairy Cows
Bibliographic record
Abstract
subclinical) is most often treated with intrauterine infusion of a specific formulation of cephapirin (Metricure, Merk) which has beneficial effects on clinical cure and subsequent reproductive performance [8][9][10][11][12].Although prostaglandins are still used for treatment and prevention of endometritis, there is no evidence of efficacy neither for improving reproductive efficiency nor for reducing its incidence [2], Lefebvre and Stock 2012).However, this hormone is essential in synchronization protocols for controlled breeding programs.The aim of the present article is to review non-antibiotic approaches used to treat or prevent PUDs in dairy cows. Alternative MedicineVeterinarians could substitute antibiotics for natural alternatives, especially in the global context of antimicrobial resistance and given the World Health Organization's position on the use of medically important antibiotics and the One Health program.Despite the well documented detrimental impact of PUDs on the cow reproductive health, treatment and prevention practices of farmers are not always recorded and consistent.For example, [13] have shown significant disparity as to how farmers treat metritis.To mitigate the impact of PUDs, several non-antimicrobial therapies to treat or prevent uterine diseases have been proposed.However, most of them are still in the early experimental stages and under scrutiny.In addition, the scientific merit of most in vivo studies seems to be compromised by experimental factors: absence of precise clinical definition, inconsistencies of outcomes, lack of negative controls, insufficient numbers of animals per treatment group, use of inadequate or rebutted AbstractThe ultimate goal of treating postpartum uterine diseases (PUDs) in dairy cows is to reach clinical cure in a reasonable amount of time and to improve reproductive performance while minimizing milk and meat residue issues, and consequently, reducing economic losses.Even though some local antibiotic treatments are effective to mitigate the effect of PUDs, veterinarians will eventually use more natural alternatives to meet the global context of antimicrobial resistance and protect human and animal health.Research advances have improved our understanding of the uterine involution and the ethiopathology of the different pathological postpartum conditions in dairy cows.This has opened new therapeutic and preventive approach, however, most recent research is still in the early experimental stages and under scrutiny.The aim of the present article is to review non-antibiotic approaches used to treat or prevent PUDs in dairy cows.The authors include: Chitosan microparticles, essential oils, mannose, bacteriophages, dextrose, paraffin, ozone, probiotics, antiseptics, homeopathy, apitherapy, vaccines, pegbovigrastim, recombinant IL-8, and genomic selection.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".