Probability of manifestation of fertility haplotype AH1 in tested ayrshire bulls
Bibliographic record
Abstract
The aim of the research is to study the probability of manifestation of the haplotype of fertility AH1 in Ayrshire sires with different variants of the presence of AH1C in male ancestors in the first four rows of their pedigree. Materials and methods. The material of the study was the data of the electronic database created at RRIFAGB on the presence of the haplotype AH1 in 74 sire of the Ayrshire breed of Russia, of which 22 are carriers of the genetic defect - AH1C, and the rest are free - AH1F. To find patterns in the manifestation of the haplotype in the tested bulls, we analyzed different variants of the presence of AH1C in male ancestors in four rows of the paternal and maternal sides of their pedigree with the calculation of the probability of its manifestation. The study used data from the electronic databases “Card file of Ayrshire bulls” and “Card file of mothers of Ayrshire bulls” prepared for selection and genetic analysis using the computer program “SGS-VNIIGRZH“ and data from the Canadian website www.cdn.ca. The strength of the influence of the factors "distance of the nearest carrier ancestor" and "number of carrier ancestors" in all ranks of the proband's pedigrees on the manifestation of the haplotype AH1 in bulls of the Ayrshire breed was calculated using ANOVA in Data Analysis of Microsoft Office Excel. Results. Among the tested livestock, 42.3% of bulls AH1F did not have male ancestors of AH1C in the pedigree, while AH1C bulls had 27.3% of them. It was found that with the nearest ancestor AH1C in the 4th row of the pedigree, the haplotype was manifested in only 8.3% of the tested sires, in the 3rd and 2nd rows - in 16.7%, and in the 1st - in 75.0%. The strength of the factor “distance of the nearest carrier ancestor” is 22.0%, while the factor “number of carrier ancestors” in all ranks of the proband's pedigrees is 21.0%. Ancestors of AH1С in the first two rows of the pedigree is a reliable indicator for identifying the fertility haplotype in a proband. The highest probability of manifestation of the AH1 in a proband is observed in the presence of carrier ancestors on both sides of the pedigree, including the father. Conclusion. To reduce the likelihood of manifestation of AH1 in a proband, it is necessary to prevent the presence of bulls carrying the fertility haplotype closer to the fourth row in his pedigree, and also to avoid in all ranks of the pedigree more than three AH1C males.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".