Cerebellar atrophy in non‐fluent variant primary progressive aphasia correlates with disease severity and cognitive decline
Bibliographic record
Abstract
Abstract Background The role of the cerebellum in cognitive function has been extensively investigated in the last decades. The aim of our work was to characterize cerebellar atrophy in non‐fluent variant primary progressive atrophy (nfvPPA) and to determine whether its atrophy is associated with cognitive impairment. Method Sixteen patients with nfvPPA (mean age 59.6±9.2 years, 7 males) and 10 healthy controls (65.6±11.3 years, 4 males) were included in the study. Disease duration ranged from 12 to 84 months. Notably, the patients had no clinical signs of cerebellar involvement. All participants underwent brain MRI and cognitive assessment. A whole brain VBM analysis between patients and controls was carried out using SPM12. The relationship between clinical data and grey matter atrophy of cerebellum and its distinct areas (anterior lobe, posterior lobe, vermis, left and right hemispheres) was assessed by correlation analysis using the Spearman's rank correlation coefficient. Result VBM revealed a significant decline in grey matter (GM) volume in the anterior (specifically, 4, 5 and 6 lobules) and posterior (specifically, Crus I and II, 7b and 8 lobules) cerebellar lobes bilaterally compared to controls (Figure 1). Correlation analysis revealed a significant correlation between the posterior lobe GM volume and disease severity and total Addenbrooke Cognitive Examination score (r = ‒0.62, p = 0.01 and r = 0.69, p = 0.028, respectively). No correlations with other clinical manifestations and neuropsychological findings (disease duration, total MoCA and FAB scores, semantic and literal verbal fluency, Trail Making Test part B) were detected. Conclusion The findings demonstrate that, even in the absence of clinical signs of cerebellar involvement, prominent cerebellar atrophy is characteristic of nfvPPA. This atrophy is associated with disease severity and contributes to cognitive dysfunction. The study was supported by RFBR 19‐015‐00533.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".