A novel 3D in vitro tissue model for bone‐metastasized breast cancer: A preclinical tool in drug discovery and testing
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Bone metastasis is a frequent occurrence following breast cancer. The bone‐tumor microenvironment is heterogeneous and complicated to recapitulate. The development of new chemotherapeutics is ineffective partly due to a lack of precise in vitro tissue models. We developed a three‐dimensional (3D) bone‐tumor interface model for customized chemotherapeutic screening. It comprises a plasma‐modified electrospun mat seeded with osteoblasts to mimic a bone tissue, with a cell‐seeded hydrogel layer containing more and less aggressive or noncancerous cells on top, mimicking the tumor compartment. By screening the model with doxorubicin, we observed different migratory behaviors, with IC 50 values that were largely in accordance with those cell lines' characteristics. Our 3D model reproduces the bone microenvironment and has great potential as a drug screening tool for personalized medicine.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it