Abstract TMP96: Maladaptive Plasticity In Dystonia Following Pediatric Basal Ganglia Stroke: Associations Between Structural Connectivity And Cognitive Functioning
Bibliographic record
Abstract
Background: Dystonia is one of the most common movement disorders after pediatric basal ganglia stroke, causing significant disability. It presents several months post stroke suggesting a role of maladaptive neuroplasticity in its manifestation. Children with dystonia show additional difficulties in intelligence (IQ), academics, and cognitive inhibition, beyond those associated with stroke. Objective: To examine structural connectivity in children with post-stroke dystonia and its relationship with cognitive outcomes. Method: A prospective study of children with unilateral basal ganglia stroke and dystonia and healthy controls. Diffusion tensor imaging was used to assess white matter integrity in the cingulum and superior longitudinal fasciculus (SLF) using fractional anisotropy (FA) and mean diffusivity (MD). Participants completed measures of IQ and cognitive inhibition and flexibility. Results: Six children with basal ganglia stroke and dystonia (6 female; Median age= 15.98, IQR= 4.32) and 6 neurotypical controls (3 male; Median age= 18.01, IQR= 5.13) were included. Participants were age-matched within 1-3 years. Hemispheres were matched by dominance such that if the stroke was in the dominant hemisphere the control’s dominant hemisphere was matched to the ipsilateral side and vice versa. Mann Whitney-U tests showed children with dystonia had poorer performance on measures of IQ (U= 0, p=. 002, η 2 = .69) and inhibition (U= 4.5, p= .026, η 2 = .39). FA was lower in the ipsilateral cingulum (U= 5, p= .041, η 2 = .36) and MD was higher in the ipsilateral SLF (U= 32, p= .026, η 2 = .42) in the dystonia participants. Significant associations (p< .05) were found between ipsilateral cingulum FA and IQ (r= .56), inhibition (r= .76), and flexibility (r= .60); contralateral cingulum FA and inhibition (p= .59); ipsilateral SLF FA and inhibition (r= .51) and flexibility (r= .58); and ipsilateral SLF MD and inhibition (r= -.54) and flexibility (r= -.55). Associations between the contralateral cingulum FA and IQ (r= .47, p= .060) and flexibility (r= .50, p= .051) trended to significance. Conclusion: Findings support the hypothesis that post-stroke dystonia reflects maladaptive reorganization after injury that is associated with motor and cognitive outcome.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".