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Genetic Engineering - Programmable Humans

2022· article· en· W4210545313 on OpenAlexaff
Mahmoud El Mabrouk, Z Habib Mohamed

Bibliographic record

VenueUniversity of Waterloo Journal of Undergraduate Health Research · 2022
Typearticle
Languageen
FieldNeuroscience
TopicNeuroethics, Human Enhancement, Biomedical Innovations
Canadian institutionsUniversity of Waterloo
Fundersnot available
KeywordsEngineering ethicsField (mathematics)Risk analysis (engineering)BioethicsEnvironmental ethicsComputer scienceBiologyEngineeringBusinessGenetics

Abstract

fetched live from OpenAlex

Within the last 50 years, the idea of genetic engineering to modify the human genome has surfaced, becoming an extremely revolutionary yet highly controversial topic. With rapid advances in genetic research, the machinery used to perform such gene-editing procedures has already been developed; genetically mutating humans is now possible. The question is no longer “Can we” but now, “Should we”. The ethical concerns surrounding this issue have been thoroughly discussed in the science community, causing widespread debate on whether research should be allowed in this field of study. Many scientists believe that research in this field should be encouraged to further study genetic diseases, different means of reproduction, and other life-altering concepts such as physiological and psychological enhancement. On the other hand, many believe such research should be completely prohibited as these practices can potentially become extremely problematic due to the predicted and unknown implications that could be faced as a result of genetic engineering. Never before have we had such power and control over our own biological makeup. Considering that human lives are at risk under these practices, germline genetic engineering should be universally prohibited as it is unethical, unsafe, and medically unnecessary.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.012
Threshold uncertainty score0.040

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.000
Science and technology studies0.0010.004
Scholarly communication0.0020.002
Open science0.0010.002
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0120.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.189
GPT teacher head0.368
Teacher spread0.179 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2022
Admission routes1
Has abstractyes

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