Associations between cognitive impairment and cerebrovascular reserve in different lobes during the acute stroke of anterior circulations
Bibliographic record
Abstract
Abstract Background Cognitive impairments at the acute stroke phase should not be ignored, and its potential risk factors and mechanism need to be clinically assessed. Recently, various studies revealed that reduced cerebrovascular reserve (CVR) predicts cognitive declines such as mild cognitive impairment (MCI) and dementia. However, the association of CVR in different lobes with cognitive impairment at the acute stroke phase remains unclear. In this study, we analyzed the correlation between CVR in different lobes and cognitive impairment at the acute stroke phase in cerebral infarction patients. Method This study included 125 subjects: 96 in the acute stroke phase (38 left infarction and 58 right infarction) and 29 healthy controls with no history of neurological disease. The basic sociodemographic characteristics of the two groups matched and their cognitive status was assessed by the Montreal Cognitive Assessment (MoCA). The CVR was assessed by CT perfusion imaging scans, including cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT). Results The MoCA scores of visuospatial/executive, attention, and orientation in both left and right infarctions patients significantly decreased. Nevertheless, the MoCA scores for naming, language, and delayed recall significantly only decreased in left infarction patients. The CBF of right vessels in the frontal lobe and the MTT of left vessels in the occipital lobe was negatively related to the MoCA scores of left infarction patients. The CBV of left vessels in the frontal lobe and CBF of left vessels in the parietal lobe were positively related to the MoCA scores of left infarction patients. The CBF of right vessels in the temporal lobe was negatively related to the MoCA scores of right infarction patients. Finally, the CBF of the left vessels in the temporal lobe was positively related to the MoCA scores of right infarction patients. Conclusions CVR was closely related to cognitive impairment at the acute stroke phase. Decreasing CVR might be a potential neuroimaging biomarker to predict cognitive impairment at the acute stroke phase.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".