04 / Vasoplegic effects of general anesthetics (xenon, sevoflurane and isoflurane) in elderly patients during ophthalmic surgery
Bibliographic record
Abstract
Background and Goal of Study: In the conduct of general anesthesia cardiodepressant effects of anesthetics often have a critical effect on this contingent. We have considerable experience in conducting xenon anesthesia in ophthalmic operations. The aim of the study was to compare the course of anesthesia in patients older than 50 years with concomitant pathology under conditions of general anesthesia.Materials and Methods: There was carried out a prospective comparative study during laryngeal mask combined anesthesia using xenon (group 1), n=27, sevoflurane (2), n=24 and isoflurane (3), n=23 in ophthalmic surgery. There were investigated: the indications of hemodynamics and oxygenation (the initial data, in 20, 40, 60 min), infusion volume and recovery time. Statistic study: descriptive analysis, U criterion Mann-Whitney.Results and Discussion: An average age of patients in Xe group was 65 (8), Sev - 58 (9), Iso - 59 (9) years, accompanying pathology, duration and character of the operations in the groups were comparable.The initial data between the groups differed insignificantly. In 20 minutes of anesthesia, TPR does not change in the group 1 with xenon and significantly decreases in groups 2 and 3 - by 27 and 48%, respectively (p <0.05). To stabilize hemodynamics in groups of halogenated anesthetics, a relatively larger amount of infusion was required than in the xenon group, which is unsafe in elderly patients with cardiac pathology. The recovery time of consciousness in the group 1 was 5(1) min, in the group 2 - 17(2) min, group 3 u2013 18(3) min (p <0.01).Conclusions: Xenon is an anesthetic of choice for general anesthesia in elderly patients with concomitant pathology in ophthalmic surgery. The course of anesthesia is characterized by stable hemodynamics, the recovery from anesthesia is quick and comfortable.Gupta u0410, Stierer u0422, Zukerman R et al. Anesth. Analg. 2004; 98:632-641
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".